It looks like you have an industrial area on the left and a yard in the middle. One thing you might consider is reversing their location: have the yard on the end and the industry in the middle. This will make operation easier: your spurs on the left are all facing-point spurs, which means that trains coming out of the yard will have to make a runaround move to spot cars on those spurs. Which may be part of your plan, I suppose. Making them trailing point spurs wouldn't make much sense either, since you would run short of places to spot the train.
If you do keep the yard in the middle, consider making it a double-ended yard with ladders on both ends to make it easier to work in both directions. It would then make sense to put more industries on the right-hand side, or maybe something like an interchange, to suggest traffic on and off the layout--maybe even cassettes to load trains on and off of the right-hand side. Operation would thus be about receiving incoming cars from the interchange and "offstage," making trains in the yard, and then spotting cars in the industrial area.