I don't know too many details. NCE has a USB Interface. NCE2 They don't give you much info on it. As I understand it you need a decoder software program and USB cable to use it. That said, you can use the interface to program your decoder CV's and even accessory decoders. So instead of doing your programming with the cab you can use the computer to make the job easier. As for operating the layout with a computer, I'm not sure if it goes that far. The prospect has me intrigued though. I should add that I think with some properly designed software you could use the USB port to completely interface with your layout. I don't know if such a thing exists yet though.